P424

Reprinted from Archives internationales de Pharmacodynamie et de Thérapie

Vol. 198 - No. I - July 1972

Pulmonary Arterial Blood Pressure in Closed Chest Rats Changes After Catecholamines, Histamine and Serotonin (1)

J. HERGET AND F. PALEČEK

Department of Pathological Physiology, Faculty of Pediatrics,

Charles University, Praha, Czechoslovakia

Abstract - Using a method of pulmonary artery catheterization in closed chest rats the normal ventricular systolic blood pressure was found to be 28 ± 0.9 mm Hg, the maximal pulmonary arterial blood pressure 23 ± 0.6 mm Hg, the minimal pulmonary arterial blood pressure 12 ± 0.5 mm Hg, and the mean pulmonary arterial blood pressure 18 ± 0.5 mm Hg. After administration of epinephrine pulmonary arterial blood pressure increased. The response to norepinephrine was not identical in all animals. After administration of a low dose of histamine no change was noticed. Following a high dose a decrease of pulmonary arterial blood pressure occurred. After a low dose of serotonin there were no significant changes in pulmonary arterial blood pressure. An increase was noticed after a large dose of serotonin applied during artificial ventilation. The method is proposed as a suitable means of studying the pharmacological effects of drugs on pulmonary circulation in small laboratory animals.